Date Published: 26 September 2006

Microscopic Brain Damage Detected in Early Alzheimer's Disease

Researchers have developed a new computer-aided analysis technique to identify early cellular damage in Alzheimer's disease (AD). The study is featured in the October issue of Radiology.

" With increasing longevity among the population, the incidence of AD is expected to rise rapidly, creating a great burden not only for patients and their families, but also for society," said Min-Ying Su, Ph.D., author and associate professor in the Department of Radiological Sciences & the Tu and Yuen Center for Functional Onco-Imaging at the University of California at Irvine.

" Our methods may enable earlier diagnosis of AD, allowing earlier intervention to slow down disease progression," she added.

As Alzheimer's disease progresses, cell membranes in the brain may be damaged, allowing water molecules to move throughout the brain more freely. This phenomenon can disrupt neural processes and cause neuron cells to die, leading to brain atrophy. This process of cellular damage causes an increase in the "apparent diffusion coefficient," or ADC, which is a measurement used to study the distribution of water in the brain.

Thirteen elderly patients with mild cognitive impairment (MCI) were enrolled in Dr. Su's study. Patients with MCI are at high risk for developing AD. These 13 patients and 13 elderly control subjects underwent magnetic resonance imaging (MRI) of the brain and performed recall tasks. On MRI images, ADC values were measured in gray- and white-matter regions by using the computer-aided analysis program. Findings were compared between patients and healthy controls.

The computerized mapping technique allowed researchers to evaluate apparent diffusion coefficient values in large regions of the brain. In patients with mild cognitive impairment, researchers identified regions of brain atrophy and increased water content in white-matter areas. Additionally, high apparent diffusion coefficient values were found in the hippocampus, temporal lobe gray matter and the corpus callosum, which connects the two cerebral hemispheres. The apparent diffusion coefficient values in the hippocampus were significantly correlated with worse memory performance scores.

" The results have supported our objective to develop a computer-based analysis technique that can analyze different regions in the entire brain, to provide a comprehensive evaluation of cellular changes," Dr. Su said.

Until now, apparent diffusion coefficient values from gray matter in various lobes of the brain have not been reported, due to the difficulty of obtaining measurements in these regions. This new technology may allow researchers to learn more about how Alzheimer's disease develops in the brain and to cultivate better treatment strategies for patients based on their individual cognitive needs.

" Patients with MCI who are very likely to progress to Alzheimer's disease may start early treatment interventions, while patients who may remain stable with mild cognitive impairment can be spared from treatment and the associated side effects," added Dr. Su.

" The diagnostic accuracy in identifying AD needs to be greatly improved."

Alzheimer's disease is the most common form of dementia, affecting more than 4.5 million Americans. Patients diagnosed with Alzheimer's disease have an average life expectancy of eight years after initial symptoms appear.

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